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- The affected person underwent successful percutaneous intervention of the best coronary artery.
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However, testosterone in physiologic doses could even be useful in patients with angina , have higher ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in men with established coronary artery disease . Therefore, an interaction of endogenous factors of the patient’s danger profile as properly as the testosterone dosing could additionally be issues of whether antagonistic events happen. Erythrocytosis has been reported as a possible effect of testosterone, which can be beneficial in sufferers with anemia.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac danger elements using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the right coronary artery. Physicians and patients ought to concentrate on the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.
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Patients also may be taking concomitant stimulants, such as ephedra, which might confound knowledge and the potential for antagonistic events. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Moreover, testosterone has been used in the treatment of lowered muscle mass and bone density in addition to anemia. The position testosterone could play within the growth of heart problems has more and more turn out to be the subject of present interest . Supraphysiologic doses of anabolic-androgenic steroids , which embrace greater than 30 natural and synthetic derivatives of testosterone, may cause a wide spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical apply recently. Other frequent potential antagonistic results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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